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Proton Pump
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Proton Pump Related Products (183)
Related Products (183)
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Antibodies (1)
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Rabeprazole-13C,d3 sodium
0 ImagesCat. No.: HY-B0656AS3Synonyms: LY307640-13C,d3 sodiumRabeprazole-13C,d3 (sodium) (LY307640-13C,d3 (sodium)) is 13C labeled Rabeprazole (sodium). Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux. -
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Abeprazan hydrochloride (Standard)
0 ImagesCat. No.: HY-109079ARCAS No.: 1902954-87-3Synonyms: DWP14012 hydrochloride (Standard); Fexuprazan hydrochloride (Standard)Abeprazan hydrochloride (Standard) is the analytical standard of Abeprazan (hydrochloride) (HY-109079A). This product is intended for research and analytical applications. Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker. Abeprazan hydrochloride inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan hydrochloride is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases. -
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4-Hydroxy omeprazole sulfide
0 ImagesCat. No.: HY-138187CAS No.: 103876-98-8 -
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S-Pantoprazole sodium trihydrate
0 ImagesCat. No.: HY-17507ECAS No.: 1416988-58-3S-Pantoprazole (sodium trihydrate) is related to Pantoprazole (HY-17507) that plays an important roles in gastric acid secretion disorder-related diseases, or as proton pump inhibitor. -
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Tegoprazan (Standard)
0 ImagesSynonyms: CJ-12420 (Standard); RQ-00000004 (Standard)Tegoprazan (Standard) is the analytical standard of Tegoprazan. This product is intended for research and analytical applications. Tegoprazan (CJ-12420), a potassium-competitive acid blocker, is a potent, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC50 values ranging from 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPases in vitro. -
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KR-60436
0 ImagesCat. No.: HY-124158CAS No.: 220853-65-6KR-60436 is a reversible H+/K+-ATPase inhibitor. KR-60436 can potently inhibit the metabolism of CYP1A2 substrates. -
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Picoprazole
0 ImagesCat. No.: HY-15384CAS No.: 78090-11-6Picoprazole is a specific inhibitor of H+/K+-ATPase with IC50 of 3.1±0.4 μM. -
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SKF96067
0 ImagesCat. No.: HY-U00042CAS No.: 115607-61-9SKF96067 is a reversible inhibitor of the gastric H+/K+-ATPase. -
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Rabeprazole (Standard)
0 ImagesCat. No.: HY-B0656RCAS No.: 117976-89-3Synonyms: LY307640 (Standard)Rabeprazole (Standard) is the analytical standard of Rabeprazole. This product is intended for research and analytical applications. Rabeprazole (LY307640) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux. -
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2-(Trifluoromethyl)cinnamic acid
0 Images2-(Trifluoromethyl)cinnamic acid is a cinnamic acid derivative that inhibits the proton pump (H+/K+-ATPase), thereby reducing gastric acid secretion. 2-(Trifluoromethyl)cinnamic acid also improves delayed gastric emptying and can be used in research on gastric diseases such as acute gastritis and gastric ulcers. -
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Omeprazole-d3 sodium
0 ImagesCat. No.: HY-B0113S4Synonyms: H 16868-d3 sodiumOmeprazole-d3 sodium is deuterated labeled Omeprazole (HY-B0113). Omeprazole sodium (H 16868) is an orally active H+,K+-ATPase inhibitor and a proton pump inhibitor. Omeprazole sodium competitively inhibits CYP2C19, CYP3A4, and CYP2C9 activity. Omeprazole sodium inhibits gastric acid secretion and can be used for acid-related gastrointestinal disorders. Omeprazole sodium inhibits pancreatic cancer cell proliferation, induces apoptosis, autophagosome accumulation (elevated LC3-I and LC3-II levels), oxidative stress, and cytogenetic imbalance, modulates lysosomal transport, reduces inflammatory cytokines. Omeprazole sodium alters small intestinal morphology and magnesium absorption, and induces gastric mucosa morphologic changes. Omeprazole sodium aslo has neuroprotective and antibacterial effects. -
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(±)-Vasicine (Standard)
0 Images(±)-Vasicine (Standard) is the analytical standard of (±)-Vasicine (HY-N7031). This product is intended for research and analytical applications. (±)-Vasicine is the racemate of Vasicine. Vasicine (Peganine) significantly inhibits H+-K+-ATPase activity in vitro with an IC50 of 73.47 μg/mL. Anti-ulcer activity. Vasicine shows significant anti-secretory, antioxidant and cytoprotective effect. -
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Rabeprazole-13C,d3
0 ImagesCat. No.: HY-B0656S1CAS No.: 1261392-48-6Synonyms: LY307640-13C,d3Rabeprazole-13C,d3 is a deuterated labeled Rabeprazole. Rabeprazole (LY307640) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux. -
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Concanamycin E
0 ImagesCat. No.: HY-N14425CAS No.: 144450-35-1Concanamycin E is a lysosomal acidification inhibitor with an IC50 value of 0.038 nM. -
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Pantoprazole sulfone
0 ImagesCat. No.: HY-117225CAS No.: 127780-16-9Pantoprazole sulfone is a metabolite of the gastric H+/K+ ATPase pump inhibitor Pantoprazole (HY-17507). -
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Nepaprazole
0 ImagesCat. No.: HY-19153CAS No.: 156601-79-5Synonyms: rel-TY-11345 free baseNepaprazole (rel-TY-11345 free base) is a proton pump inhibitor. Nepaprazole inhibits H+/K+-ATPase activity in isolated rabbit gastric mucosal microsomes with the IC50 values of 5.8 μM and 9.9 μM at pH 6.0 and pH 7.4, respectively. Nepaprazole can be used for study of peptic ulcer diseases. -
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Soraprazan (Standard)
0 ImagesCat. No.: HY-100414RCAS No.: 261944-46-1Synonyms: BYK61359 (Standard)Soraprazan (Standard) is the analytical standard of Soraprazan (HY-100414). This product is intended for research and analytical applications. Soraprazan (BYK61359) is a selective, reversible K-competitive inhibitor of the H,K-ATPase (Ki=6.4 nM), with an IC50 of 0.19 μM in gastric glands. Soraprazan binds to the H,K-ATPase with a Kd of 28.27 nM. Soraprazan shows immediate inhibition of acid secretion and is more than 2000-fold selective for H,K-ATPase over Na,K- and Ca-ATPases. -
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Abeprazan (Standard)
0 ImagesCat. No.: HY-109079RCAS No.: 1902954-60-2Synonyms: DWP14012 (Standard); Fexuprazan (Standard)Abeprazan (Standard) is the analytical standard of Abeprazan (HY-109079). This product is intended for research and analytical applications. Abeprazan (DWP14012) is a potassium-competitive acid blocker. Abeprazan inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases. -
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AHR-9294
0 ImagesCat. No.: HY-119991CAS No.: 84023-64-3AHR-9294 is an inhibitor of the H+ pump enzyme and H, K-ATPase. AHR-9294 inhibits acid secretion in vivo. -
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Tenatoprazole (Standard)
0 ImagesSynonyms: TU-199 (Standard)Tenatoprazole (Standard) is the analytical standard of Tenatoprazole. This product is intended for research and analytical applications. Tenatoprazole (TU-199) is an orally active imidazopyridine-based proton pump inhibitor with a prolonged plasma half-life. Tenatoprazole inhibits hog gastric H+/K+-ATPase activity with an IC50 of 6.2 μM. Tenatoprazole blocks the interaction of ubiquitin with the ESCRT-1 factor Tsg101, inhibits production of several enveloped viruses, including EBV. -
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